Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 19 June 2012
Vol. 5, Issue 229, p. ra44
[DOI: 10.1126/scisignal.2003111]

RESEARCH ARTICLES

Editor's Summary

Targeting the Lipid Ligand to Regulate Transcription
Steroidogenic factor 1 (SF-1) is a nuclear receptor that transcriptionally activates genes involved in sexual development and reproduction. Blind et al. found that phosphatidylinositol 4,5-bisphosphate (PIP2) bound to SF-1 was phosphorylated by inositol polyphosphate multikinase (IPMK) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). Conversely, the lipid phosphatase PTEN dephosphorylated the SF-1–PIP3 complex. The transcriptional activity of SF-1 was decreased in cells after inhibiting IPMK and increased in cells overexpressing PTEN. Thus, phosphorylation of its associated lipid, rather than the nuclear receptor itself, activates SF-1 and identifies another signaling role for nuclear phosphoinositides.

Citation: R. D. Blind, M. Suzawa, H. A. Ingraham, Direct Modification and Activation of a Nuclear Receptor–PIP2 Complex by the Inositol Lipid Kinase IPMK. Sci. Signal. 5, ra44 (2012).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Inositol polyphosphate multikinase is a transcriptional coactivator required for immediate early gene induction.
R. Xu, B. D. Paul, D. R. Smith, R. Tyagi, F. Rao, A. B. Khan, D. J. Blech, M. S. Vandiver, M. M. Harraz, P. Guha, et al. (2013)
PNAS 110, 16181-16186
   Abstract »    Full Text »    PDF »
Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation.
T. Balla (2013)
Physiol Rev 93, 1019-1137
   Abstract »    Full Text »    PDF »
Inositol Polyphosphate Multikinase Is a Coactivator of p53-Mediated Transcription and Cell Death.
R. Xu, N. Sen, B. D. Paul, A. M. Snowman, F. Rao, M. S. Vandiver, J. Xu, and S. H. Snyder (2013)
Science Signaling 6, ra22
   Abstract »    Full Text »    PDF »
Arginine Transcriptional Response Does Not Require Inositol Phosphate Synthesis.
D. Bosch and A. Saiardi (2012)
J. Biol. Chem. 287, 38347-38355
   Abstract »    Full Text »    PDF »
Acid Ceramidase (ASAH1) Represses Steroidogenic Factor 1-Dependent Gene Transcription in H295R Human Adrenocortical Cells by Binding to the Receptor.
N. C. Lucki, D. Li, S. Bandyopadhyay, E. Wang, A. H. Merrill, and M. B. Sewer (2012)
Mol. Cell. Biol. 32, 4419-4431
   Abstract »    Full Text »    PDF »
Science Signaling Podcast: 19 June 2012.
H. A. Ingraham, R. D. Blind, and A. M. VanHook (2012)
Science Signaling 5, pc13
   Abstract »    Full Text »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882