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Sci. Signal., 19 June 2012
Vol. 5, Issue 229, p. ra45
[DOI: 10.1126/scisignal.2002873]

RESEARCH ARTICLES

Editor's Summary

Enhancing Regulatory T Cell Function
Some therapies designed to help patients suffering from autoimmune diseases or recovering from organ transplant involve the removal of the patient’s regulatory T cells (Tregs), which suppress the undesirable proinflammatory actions of effector T cells, so that they can be expanded in number ex vivo before being put back into the patient. One problem associated with this approach is that the phenotype of the administered Tregs is unstable, and so their suppressive function is lost over time. Previous studies have shown that inhibition of certain members of the family of histone deacetylases (HDACs) enhances the function of Tregs. Through experiments with mice deficient in distinct HDACs and treated with HDAC-specific inhibitors, Beier et al. have demonstrated the mechanisms by which the simultaneous inhibition of combinations of distinct HDACs improved the suppressive function of Tregs and enhanced their stability, which suggests that such an approach may be of benefit to patients reliant on such therapies.

Citation: U. H. Beier, L. Wang, R. Han, T. Akimova, Y. Liu, W. W. Hancock, Histone Deacetylases 6 and 9 and Sirtuin-1 Control Foxp3+ Regulatory T Cell Function Through Shared and Isoform-Specific Mechanisms. Sci. Signal. 5, ra45 (2012).

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis.
P. M. Smith, M. R. Howitt, N. Panikov, M. Michaud, C. A. Gallini, M. Bohlooly-Y, J. N. Glickman, and W. S. Garrett (2013)
Science 341, 569-573
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T Cell Signaling Targets for Enhancing Regulatory or Effector Function.
F. Pan, H. Fan, Z. Liu, and S. Jiang (2012)
Science Signaling 5, pe32
   Abstract »    Full Text »    PDF »

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