Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 26 June 2012
Vol. 5, Issue 230, p. ra46
[DOI: 10.1126/scisignal.2002796]

RESEARCH ARTICLES

Editor's Summary

PD-1 Inhibits the Cell Cycle Machinery
Effector T cells are stimulated through the T cell receptor (TCR) to become activated and proliferate. However, inhibitory receptors, such as PD-1, counteract these stimulatory signals and block T cell proliferation. Patsoukis et al. found that PD-1–mediated inhibition of Akt and Ras signaling pathways affected a number of components of the cell cycle machinery to "lock" T cells in the G1 phase and prevent their proliferation. These mechanistic details may help in the development of therapeutics designed to block PD-1 function and enable T cell activation in the context of antiviral or antitumor responses.

Citation: N. Patsoukis, J. Brown, V. Petkova, F. Liu, L. Li, V. A. Boussiotis, Selective Effects of PD-1 on Akt and Ras Pathways Regulate Molecular Components of the Cell Cycle and Inhibit T Cell Proliferation. Sci. Signal. 5, ra46 (2012).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
KLRG1 Impairs CD4+ T Cell Responses via p16ink4a and p27kip1 Pathways: Role in Hepatitis B Vaccine Failure in Individuals with Hepatitis C Virus Infection.
L. Shi, J. M. Wang, J. P. Ren, Y. Q. Cheng, R. S. Ying, X. Y. Wu, S. M. Lin, J. W. D. Griffin, G. Y. Li, J. P. Moorman, et al. (2014)
J. Immunol. 192, 649-657
   Abstract »    Full Text »    PDF »
PD-1 Increases PTEN Phosphatase Activity While Decreasing PTEN Protein Stability by Inhibiting Casein Kinase 2.
N. Patsoukis, L. Li, D. Sari, V. Petkova, and V. A. Boussiotis (2013)
Mol. Cell. Biol. 33, 3091-3098
   Abstract »    Full Text »    PDF »
Strength of PD-1 signaling differentially affects T-cell effector functions.
F. Wei, S. Zhong, Z. Ma, H. Kong, A. Medvec, R. Ahmed, G. J. Freeman, M. Krogsgaard, and J. L. Riley (2013)
PNAS 110, E2480-E2489
   Abstract »    Full Text »    PDF »
T Cell Signaling Targets for Enhancing Regulatory or Effector Function.
F. Pan, H. Fan, Z. Liu, and S. Jiang (2012)
Science Signaling 5, pe32
   Abstract »    Full Text »    PDF »
Science Signaling Podcast: 26 June 2012.
V. A. Boussiotis and A. M. VanHook (2012)
Science Signaling 5, pc14
   Abstract »    Full Text »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882