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Sci. Signal., 26 June 2012
Vol. 5, Issue 230, p. ra46
PD-1 Inhibits the Cell Cycle Machinery
Effector T cells are stimulated through the T cell receptor (TCR) to become activated and proliferate. However, inhibitory receptors, such as PD-1, counteract these stimulatory signals and block T cell proliferation. Patsoukis et al. found that PD-1–mediated inhibition of Akt and Ras signaling pathways affected a number of components of the cell cycle machinery to "lock" T cells in the G1 phase and prevent their proliferation. These mechanistic details may help in the development of therapeutics designed to block PD-1 function and enable T cell activation in the context of antiviral or antitumor responses.
Citation: N. Patsoukis, J. Brown, V. Petkova, F. Liu, L. Li, V. A. Boussiotis, Selective Effects of PD-1 on Akt and Ras Pathways Regulate Molecular Components of the Cell Cycle and Inhibit T Cell Proliferation. Sci. Signal.5, ra46 (2012).