Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Sci. Signal., 10 July 2012
Vol. 5, Issue 232, p. ra49
Converging on an Adaptor for Deadly Activation
Natural killer (NK) cells target and kill virally infected cells and tumor cells, and their activation depends on the integration of responses to activating and inhibitory cell-surface receptors. Even in the absence of inhibitory receptor signaling, stimulation of an individual activating receptor fails to activate NK cells because of cell-intrinsic inhibition of signaling. However, combined stimulation of particular pairs of activating receptors results in a synergistic response that crosses the threshold required for cellular activation. Kim and Long found that pairs of activating receptors that enabled human NK cell activation led to the phosphorylation of a pair of complementary tyrosine residues in the adaptor protein SLP-76, whereas combined stimulation of nonsynergistic receptors failed to phosphorylate both tyrosines. Phosphorylation of both residues in SLP-76 was required for downstream signaling that led to cytokine production and target cell killing. Thus, SLP-76 acts as a molecular checkpoint that controls the activation of NK cells.
Citation: H. S. Kim, E. O. Long, Complementary Phosphorylation Sites in the Adaptor Protein SLP-76 Promote Synergistic Activation of Natural Killer Cells. Sci. Signal.5, ra49 (2012).
The editors suggest the following Related Resources on Science sites:
In Science Signaling
Ernesto Andrianantoandro and John F. Foley (31 July 2012) Sci. Signal.5 (235), eg8.
[DOI: 10.1126/scisignal.2003412] |Abstract »|Full Text »|PDF »
Leo M. Carlin, Rachel Evans, Hanna Milewicz, Luis Fernandes, Daniel R. Matthews, Michela Perani, James Levitt, Melanie D. Keppler, James Monypenny, Ton Coolen, Paul R. Barber, Borivoj Vojnovic, Klaus Suhling, Franca Fraternali, Simon Ameer-Beg, Peter J. Parker, N. Shaun B. Thomas, and Tony Ng (29 November 2011) Sci. Signal.4 (201), ra81.
[DOI: 10.1126/scisignal.2001729] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »
Sophie Guia, Baptiste N. Jaeger, Stefan Piatek, Sébastien Mailfert, Tomasz Trombik, Aurore Fenis, Nicolas Chevrier, Thierry Walzer, Yann M. Kerdiles, Didier Marguet, Eric Vivier, and Sophie Ugolini (5 April 2011) Sci. Signal.4 (167), ra21.
[DOI: 10.1126/scisignal.2001608] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »