Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 24 July 2012
Vol. 5, Issue 234, p. ra53
[DOI: 10.1126/scisignal.2002859]


Editor's Summary

Cytosolic Notch Protects T Cells
Effector T cells direct the immune response against pathogens, whereas regulatory T cells (Tregs) suppress effector T cell function to keep the immune response in check. In addition to their opposing functions, these cells have different responses when survival cytokines are unavailable. Effector T cells undergo apoptosis, whereas Tregs survive (see the Perspective by Minter and Osborne). Perumalsamy et al. found that the differential survival of effector T cells and Tregs correlated with differential signaling by the receptor Notch1. Whereas the Notch1 intracellular domain (NICD) was localized to the nucleus in effector T cells, it was localized in the cytosol of Tregs, and blockade of Notch1 signaling or prevention of the cytosolic localization of NICD abolished the protection of Tregs from apoptosis. Treg survival depended on interactions between Notch1 and components of the phosphatidylinositol 3-kinase and mammalian target of rapamycin signaling pathways. Together, these data implicate spatial control of Notch signaling components in the protection of specific T cell subsets from apoptosis.

Citation: L. R. Perumalsamy, N. Marcel, S. Kulkarni, F. Radtke, A. Sarin, Distinct Spatial and Molecular Features of Notch Pathway Assembly in Regulatory T Cells. Sci. Signal. 5, ra53 (2012).

Read the Full Text

Noncanonical NOTCH Signaling Limits Self-Renewal of Human Epithelial and Induced Pluripotent Stem Cells through ROCK Activation.
T. Yugawa, K. Nishino, S.-i. Ohno, T. Nakahara, M. Fujita, N. Goshima, A. Umezawa, and T. Kiyono (2013)
Mol. Cell. Biol. 33, 4434-4447
   Abstract »    Full Text »    PDF »
Notch and the Survival of Regulatory T Cells: Location Is Everything!.
L. M. Minter and B. A. Osborne (2012)
Science Signaling 5, pe31
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882