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Sci. Signal., 31 July 2012
Vol. 5, Issue 235, p. ra54
Boosting Antibody Production
The initial exposure of naïve B cells that have IgM B cell receptors (BCRs) on their surface to a foreign antigen produces a primary antibody response and generates memory B cells that have IgG BCRs, which respond to subsequent encounters with the same antigen by rapidly producing large amounts of antibodies. Liu et al. investigated differences in the signaling capacities of IgG and IgM BCRs and found that the scaffold protein SAP97 bound to IgG, but not IgM, BCRs at the immunological synapse, enabling BCR clustering and enhanced signaling. These findings may provide therapeutic targets to block enhanced BCR activation in autoimmune disease and in some B cell tumors.
Citation: W. Liu, E. Chen, X. W. Zhao, Z. P. Wan, Y. R. Gao, A. Davey, E. Huang, L. Zhang, J. Crocetti, G. Sandoval, M. G. Joyce, C. Miceli, J. Lukszo, L. Aravind, W. Swat, J. Brzostowski, S. K. Pierce, The Scaffolding Protein Synapse-Associated Protein 97 Is Required for Enhanced Signaling Through Isotype-Switched IgG Memory B Cell Receptors. Sci. Signal.5, ra54 (2012).
Annemiek B. van Spriel, Sandra de Keijzer, Alie van der Schaaf, Kate H. Gartlan, Mariam Sofi, Amanda Light, Peter C. Linssen, Jan B. Boezeman, Malou Zuidscherwoude, Inge Reinieren-Beeren, Alessandra Cambi, Fabienne Mackay, David M. Tarlinton, Carl G. Figdor, and Mark D. Wright (13 November 2012) Sci. Signal.5 (250), ra82.
[DOI: 10.1126/scisignal.2003113] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »
Ernesto Andrianantoandro and John F. Foley (31 July 2012) Sci. Signal.5 (235), eg8.
[DOI: 10.1126/scisignal.2003412] |Abstract »|Full Text »|PDF »