Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Sci. Signal., 7 August 2012
Vol. 5, Issue 236, p. ra57
Ribosomes are the cellular sites for protein synthesis, and ribosomal RNA is transcribed in nuclear structures called nucleoli. The higher proliferation rate of tumor cells requires an increased rate of protein synthesis, and enhancing the rates of ribosomal RNA transcription and the production of ribosomes confers a growth advantage. Delloye-Bourgeois et al. characterized a truncated isoform of netrin-1 called N-netrin-1 that, unlike the full-length form, was not secreted but instead localized to nucleoli where it interacted with proteins involved in ribosomal RNA transcription. Overexpression of N-netrin-1 increased the cytoplasmic pool of ribosomes, proliferation of cultured cells, and tumor growth in an in vivo model. N-netrin-1 was also detected in some cancer cell lines and human cancers. The current antitumor agents targeting the full-length netrin-1 isoform cannot enter cells and, thus, would likely not affect the pro-tumor activity of nucleolar N-netrin-1.
Citation: C. Delloye-Bourgeois, D. Goldschneider, A. Paradisi, G. Therizols, S. Belin, S. Hacot, M. Rosa-Calatrava, J.-Y. Scoazec, J.-J. Diaz, A. Bernet, P. Mehlen, Nucleolar Localization of a Netrin-1 Isoform Enhances Tumor Cell Proliferation. Sci. Signal.5, ra57 (2012).
The editors suggest the following Related Resources on Science sites:
In Science Signaling
Ralph A. Neumüller, Thomas Gross, Anastasia A. Samsonova, Arunachalam Vinayagam, Michael Buckner, Karen Founk, Yanhui Hu, Sara Sharifpoor, Adam P. Rosebrock, Brenda Andrews, Fred Winston, and Norbert Perrimon (20 August 2013) Sci. Signal.6 (289), ra70.
[DOI: 10.1126/scisignal.2004145] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »
Joanna C. Chan, Katherine M. Hannan, Kim Riddell, Pui Yee Ng, Abigail Peck, Rachel S. Lee, Sandy Hung, Megan V. Astle, Megan Bywater, Meaghan Wall, Gretchen Poortinga, Katarzyna Jastrzebski, Karen E. Sheppard, Brian A. Hemmings, Michael N. Hall, Ricky W. Johnstone, Grant A. McArthur, Ross D. Hannan, and Richard B. Pearson (30 August 2011) Sci. Signal.4 (188), ra56.
[DOI: 10.1126/scisignal.2001754] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Combining chemotherapeutic agents and netrin-1 interference potentiates cancer cell death.
A. Paradisi, M. Creveaux, B. Gibert, G. Devailly, E. Redoulez, D. Neves, E. Cleyssac, I. Treilleux, C. Klein, G. Niederfellner, et al. (2013)
EMBO Mol Med.
|Abstract »|Full Text »|PDF »
Revisiting the Nucleolus: From Marker to Dynamic Integrator of Cancer Signaling.