Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 14 August 2012
Vol. 5, Issue 237, p. ra58
[DOI: 10.1126/scisignal.2002941]

RESEARCH ARTICLES

Editor's Summary

Rabies Virus Relocalizes PTEN
Virulent strains of rabies virus infect neurons and promote survival of the infected cells to favor viral replication. Among the host factors that inhibit neuronal survival are the phosphatase PTEN and one of its binding partners, the kinase MAST2. PTEN and MAST2 interact through the PDZ domain of MAST2 and the PDZ domain–binding site (PDZ-BS) of PTEN. Terrien et al. found that the rabies virus glycoprotein (G protein), which contains a PDZ-BS, disrupted the MAST2-PTEN complex in infected cells. Structural analysis showed that the surfaces of PTEN and G protein that interacted with MAST2 were similar and contained previously uncharacterized PDZ-binding regions. Finally, disruption of the MAST2-PTEN complex by viral G protein resulted in the relocalization of PTEN from the nucleus to the cytoplasm. Together, these data suggest that competition between viral G protein and MAST2 for binding to PTEN plays a role in the survival of infected cells.

Citation: E. Terrien, A. Chaffotte, M. Lafage, Z. Khan, C. Préhaud, F. Cordier, C. Simenel, M. Delepierre, H. Buc, M. Lafon, N. Wolff, Interference with the PTEN-MAST2 Interaction by a Viral Protein Leads to Cellular Relocalization of PTEN. Sci. Signal. 5, ra58 (2012).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Synthetic Lethal Targeting of PTEN-Deficient Cancer Cells Using Selective Disruption of Polynucleotide Kinase/Phosphatase.
T. R. Mereniuk, M. A. M. El Gendy, A. M. Mendes-Pereira, C. J. Lord, S. Ghosh, E. Foley, A. Ashworth, and M. Weinfeld (2013)
Mol. Cancer Ther. 12, 2135-2144
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882