Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 16 October 2012
Vol. 5, Issue 246, p. ra75
[DOI: 10.1126/scisignal.2003086]


Editor's Summary

Noncanonical NF-{kappa}B Signaling Gets Muscular
Skeletal muscle development (myogenesis) occurs through the fusion of single myoblasts to produce a multinucleated muscle fiber. Previous studies suggested that the canonical NF-{kappa}B pathway inhibits myogenesis. Enwere et al. showed that loss or inhibition of cIAP1, an inhibitor of the noncanonical NF-{kappa}B pathway, increased the recruitment of myoblasts into myotubes. Overexpression of components of noncanonical signaling increased myoblast fusion. Furthermore, at low concentrations, the cytokine TWEAK preferentially activated the noncanonical pathway and also increased myoblast fusion. In addition to highlighting antagonism between canonical and noncanonical NF-{kappa}B signaling in regulating myogenesis, this study suggests that small-molecule IAP antagonists or administration of TWEAK could provide potential therapies for muscle injury and degenerative diseases.

Citation: E. K. Enwere, J. Holbrook, R. Lejmi-Mrad, J. Vineham, K. Timusk, B. Sivaraj, M. Isaac, D. Uehling, R. Al-awar, E. LaCasse, R. G. Korneluk, TWEAK and cIAP1 Regulate Myoblast Fusion Through the Noncanonical NF-{kappa}B Signaling Pathway. Sci. Signal. 5, ra75 (2012).

Read the Full Text

Proinflammatory Cytokine Tumor Necrosis Factor (TNF)-like Weak Inducer of Apoptosis (TWEAK) Suppresses Satellite Cell Self-renewal through Inversely Modulating Notch and NF-{kappa}B Signaling Pathways.
Y. Ogura, V. Mishra, S. M. Hindi, S. Kuang, and A. Kumar (2013)
J. Biol. Chem. 288, 35159-35169
   Abstract »    Full Text »    PDF »
Signaling Mechanisms in Mammalian Myoblast Fusion.
S. M. Hindi, M. M. Tajrishi, and A. Kumar (2013)
Science Signaling 6, re2
   Abstract »    Full Text »    PDF »
Loss of cIAP1 attenuates soleus muscle pathology and improves diaphragm function in mdx mice.
E. K. Enwere, L. Boudreault, J. Holbrook, K. Timusk, N. Earl, E. LaCasse, J.-M. Renaud, and R. G. Korneluk (2013)
Hum. Mol. Genet. 22, 867-878
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882