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Sci. Signal., 6 November 2012
Vol. 5, Issue 249, p. ra79
[DOI: 10.1126/scisignal.2003257]


Editor's Summary

Targeting the Tumor Microenvironment
Phospholipase D (PLD) is an enzyme that produces the signaling lipid phosphatidic acid and promotes the proliferation, survival, invasion, and metastasis of cancer cells. Chen et al. examined the role of the PLD isoforms PLD1 and PLD2 in the tumor environment. They found that compared to wild-type mice, mice deficient in PLD1 developed smaller, less vascularized tumors as well as fewer lung metastases in a xenograft model. Furthermore, mice treated with an inhibitor of PLD1 also developed smaller tumors and fewer metastases. These results suggest that PLD1 inhibitors could be developed to treat cancer.

Citation: Q. Chen, T. Hongu, T. Sato, Y. Zhang, W. Ali, J.-A. Cavallo, A. van der Velden, H. Tian, G. Di Paolo, B. Nieswandt, Y. Kanaho, M. A. Frohman, Key Roles for the Lipid Signaling Enzyme Phospholipase D1 in the Tumor Microenvironment During Tumor Angiogenesis and Metastasis. Sci. Signal. 5, ra79 (2012).

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Phospholipase D2 Mediates Survival Signaling through Direct Regulation of Akt in Glioblastoma Cells.
R. C. Bruntz, H. E. Taylor, C. W. Lindsley, and H. A. Brown (2014)
J. Biol. Chem. 289, 600-616
   Abstract »    Full Text »    PDF »
Pharmacological Inhibition of Phospholipase D Protects Mice From Occlusive Thrombus Formation and Ischemic Stroke--Brief Report.
D. Stegner, I. Thielmann, P. Kraft, M. A. Frohman, G. Stoll, and B. Nieswandt (2013)
Arterioscler Thromb Vasc Biol 33, 2212-2217
   Abstract »    Full Text »    PDF »
Phosphatidic Acid-dependent Recruitment and Function of the Rac Activator DOCK1 during Dorsal Ruffle Formation.
F. Sanematsu, A. Nishikimi, M. Watanabe, T. Hongu, Y. Tanaka, Y. Kanaho, J.-F. Cote, and Y. Fukui (2013)
J. Biol. Chem. 288, 8092-8100
   Abstract »    Full Text »    PDF »
Science Signaling Podcast: 6 November 2012.
M. A. Frohman and A. M. VanHook (2012)
Science Signaling 5, pc25
   Abstract »    Full Text »

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