Sci. Signal., 11 December 2012
Multistep Process of Zyxin ActivationIn vascular cells, stretch triggers the translocation of the cytoskeletal protein zyxin from focal adhesions to the nucleus, where it drives the expression of target genes. Suresh Babu et al. characterized a multistep signaling pathway in human endothelial cells and mouse femoral arteries that led to the stretch-induced phosphorylation of zyxin and its nuclear translocation. The initial response to stretch depended on the ion channel activity of transient receptor potential channel 3 and culminated in activation of cGMP-dependent protein kinase. Similar responses were also observed in lung epithelial cells and bladder smooth muscle cells, suggesting that this mechanism of zyxin activation is shared among different mechanosensitive cells.
Citation: S. Suresh Babu, A. Wojtowicz, M. Freichel, L. Birnbaumer, M. Hecker, M. Cattaruzza, Mechanism of Stretch-Induced Activation of the Mechanotransducer Zyxin in Vascular Cells. Sci. Signal. 5, ra91 (2012).
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