Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 1 January 2013
Vol. 6, Issue 256, p. ra1
[DOI: 10.1126/scisignal.2003220]

RESEARCH ARTICLES

Editor's Summary

Crowd-Sourced Signaling
Unlike T cells, B cells respond to soluble antigens, which can either be monomeric or multimeric, the latter of which induce clustering of the B cell receptor (BCR). Antigen-mediated stimulation of T and B cells involves two distinct sets of tyrosine kinases: the Src family kinases (SFKs) and the Syk family. To understand how these two kinase families contribute to B cell activation, Mukherjee et al. mathematically modeled the contributions of SFKs and Syk to BCR signaling and verified their findings in cells. In response to soluble multimeric, BCR-clustering antigens, Syk was sufficient to mediate B cell activation, albeit with slow kinetics. However, in response to soluble monomeric antigens, which failed to induce BCR clustering, both families of kinases were required. Together, these data suggest that SFKs increase the sensitivity of B cells to monomeric antigens and ensure B cell activation.

Citation: S. Mukherjee, J. Zhu, J. Zikherman, R. Parameswaran, T. A. Kadlecek, Q. Wang, B. Au-Yeung, H. Ploegh, J. Kuriyan, J. Das, A. Weiss, Monovalent and Multivalent Ligation of the B Cell Receptor Exhibit Differential Dependence upon Syk and Src Family Kinases. Sci. Signal. 6, ra1 (2013).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Decoding the Language of Phosphorylation Site Dynamics.
L. A. Chylek (2013)
Science Signaling 6, jc2
   Abstract »    Full Text »    PDF »
Science Signaling Podcast: 1 January 2013.
A. Weiss, J. Das, and A. M. VanHook (2013)
Science Signaling 6, pc1
   Abstract »    Full Text »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882