Editor's Summary

Breaking the Endothelial Barrier

Thrombin is an endogenous ligand that induces vasoconstriction and can also disrupt the barrier formed by blood vessel endothelial cells, which leads to increased vascular permeability and leakage of plasma into the tissue. Using the thrombin-induced decrease in transendothelial resistance in two types of cultured endothelial cells as a model of barrier disruption, Shinde et al. found that the calcium-responsive protein STIM1 coupled the thrombin receptor to activation of the guanosine triphosphatase RhoA and rearrangement of the actin cytoskeleton, which contribute to loss of cell-cell contact. Surprisingly, this role did not involve various cation channels that are targets of STIM1. How STIM1 couples the thrombin receptor to RhoA remains an open question.

The editors suggest the following Related Resources on Science sites:

In Science Signaling

PERSPECTIVES
Cell Biology
STIMulating Stress Fibers in Endothelial Cells

Thomas Gudermann and Dirk Steinritz (19 March 2013)
Sci. Signal. 6 (267), pe8. [DOI: 10.1126/scisignal.2004051]
 |  Abstract »  |  Full Text »  |  PDF »

RESEARCH RESOURCES
Immunology
Systems-Level Analysis of Proteolytic Events in Increased Vascular Permeability and Complement Activation in Skin Inflammation

Ulrich auf dem Keller, Anna Prudova, Ulrich Eckhard, Barbara Fingleton, and Christopher M. Overall (15 January 2013)
Sci. Signal. 6 (258), rs2. [DOI: 10.1126/scisignal.2003512]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

REVIEWS
NEUROSCIENCE
The Abluminal Endothelial Membrane in Neurovascular Remodeling in Health and Disease

Dirk M. Hermann and Ayman ElAli (7 August 2012)
Sci. Signal. 5 (236), re4. [DOI: 10.1126/scisignal.2002886]
 |  Gloss »  |  Abstract »  |  Full Text »  |  PDF »

RESEARCH ARTICLES
Calcium Signaling
Activation of STIM1-Orai1 Involves an Intramolecular Switching Mechanism

Marek K. Korzeniowski, Isabel Martín Manjarrés, Peter Varnai, and Tamas Balla (16 November 2010)
Sci. Signal. 3 (148), ra82. [DOI: 10.1126/scisignal.2001122]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Neuroscience
STIM2 Regulates Capacitive Ca²⁺ Entry in Neurons and Plays a Key Role in Hypoxic Neuronal Cell Death

Alejandro Berna-Erro, Attila Braun, Robert Kraft, Christoph Kleinschnitz, Michael K. Schuhmann, David Stegner, Thomas Wultsch, Jens Eilers, Sven G. Meuth, Guido Stoll, and Bernhard Nieswandt (20 October 2009)
Sci. Signal. 2 (93), ra67. [DOI: 10.1126/scisignal.2000522]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

REVIEWS
Cell Biology
Dual Regulation of Endothelial Junctional Permeability

Yulia A. Komarova, Dolly Mehta, and Asrar B. Malik (13 November 2007)
Sci. STKE 2007 (412), re8. [DOI: 10.1126/stke.4122007re8]
 |  Gloss »  |  Abstract »  |  Full Text »  |  PDF »

REVIEWS
STKE Reviews
TRP Channels in Disease

Bernd Nilius, Thomas Voets, and John Peters (2 August 2005)
Sci. STKE 2005 (295), re8. [DOI: 10.1126/stke.2952005re8]
 |  Gloss »  |  Abstract »  |  Full Text »  |  PDF »

In Science Magazine

EDITORS' CHOICE: HIGHLIGHTS OF THE RECENT LITERATURE
Understanding the STIM1-ulous

L. Bryan Ray (29 March 2013)
Science 339 (6127), 1497-b. [DOI: 10.1126/science.339.6127.1497-b]
 |  Full Text »  |  PDF »

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES: