Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 19 March 2013
Vol. 6, Issue 267, p. ra18
[DOI: 10.1126/scisignal.2003425]


Editor's Summary

Breaking the Endothelial Barrier
Thrombin is an endogenous ligand that induces vasoconstriction and can also disrupt the barrier formed by blood vessel endothelial cells, which leads to increased vascular permeability and leakage of plasma into the tissue. Using the thrombin-induced decrease in transendothelial resistance in two types of cultured endothelial cells as a model of barrier disruption, Shinde et al. found that the calcium-responsive protein STIM1 coupled the thrombin receptor to activation of the guanosine triphosphatase RhoA and rearrangement of the actin cytoskeleton, which contribute to loss of cell-cell contact. Surprisingly, this role did not involve various cation channels that are targets of STIM1. How STIM1 couples the thrombin receptor to RhoA remains an open question.

Citation: A. V. Shinde, R. K. Motiani, X. Zhang, I. F. Abdullaev, A. P. Adam, J. C. González-Cobos, W. Zhang, K. Matrougui, P. A. Vincent, M. Trebak, STIM1 Controls Endothelial Barrier Function Independently of Orai1 and Ca2+ Entry. Sci. Signal. 6, ra18 (2013).

Read the Full Text

Functional properties of ion channels and transporters in tumour vascularization.
A. Fiorio Pla and L. Munaron (2014)
Phil Trans R Soc B 369, 20130103
   Abstract »    Full Text »    PDF »
Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis.
V. Nesin, G. Wiley, M. Kousi, E.-C. Ong, T. Lehmann, D. J. Nicholl, M. Suri, N. Shahrizaila, N. Katsanis, P. M. Gaffney, et al. (2014)
PNAS 111, 4197-4202
   Abstract »    Full Text »    PDF »
Complex role of STIM1 in the activation of store-independent Orai1/3 channels.
X. Zhang, W. Zhang, J. C. Gonzalez-Cobos, I. Jardin, C. Romanin, K. Matrougui, and M. Trebak (2014)
J. Gen. Physiol. 143, 345-359
   Abstract »    Full Text »    PDF »
Mechanisms of STIM1 Activation of Store-Independent Leukotriene C4-Regulated Ca2+ Channels.
X. Zhang, J. C. Gonzalez-Cobos, R. Schindl, M. Muik, B. Ruhle, R. K. Motiani, J. M. Bisaillon, W. Zhang, M. Fahrner, M. Barroso, et al. (2013)
Mol. Cell. Biol. 33, 3715-3723
   Abstract »    Full Text »    PDF »
STIMulating Stress Fibers in Endothelial Cells.
T. Gudermann and D. Steinritz (2013)
Science Signaling 6, pe8
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882