Sci. Signal., 19 March 2013
Suppressing Cancer Growth with Vitamin EVitamin E has well-known health benefits, including an anticancer effect. Tocopherols, a dietary form of vitamin E, induce the dephosphorylation of the kinase Akt, thereby inhibiting Akt-mediated signals that promote cell metabolism, proliferation, and motility. Huang et al. found that tocopherols, which integrate into cell membranes, stimulated a site-specific dephosphorylation of Akt by recruiting both Akt and the phosphatase PHLPP1 to the cell membrane through their respective pleckstrin homology (PH) domains. Tocopherol-derived synthetic compounds showed more potent effects than natural tocopherols in mediating this inactivation of Akt and reducing the growth of xenograft prostate tumors in mice, indicating potential for drug development.
Citation: P.-H. Huang, H.-C. Chuang, C.-C. Chou, H. Wang, S.-L. Lee, H.-C. Yang, H.-C. Chiu, N. Kapuriya, D. Wang, S. K. Kulp, C.-S. Chen, Vitamin E Facilitates the Inactivation of the Kinase Akt by the Phosphatase PHLPP1. Sci. Signal. 6, ra19 (2013).
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