Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 30 April 2013
Vol. 6, Issue 273, p. ra28
[DOI: 10.1126/scisignal.2003884]

RESEARCH ARTICLES

Editor's Summary

Targeting Metastasis
Gene expression can be affected not only by mutations in a gene but also by epigenetic changes, such as histone methylation status. Ding et al. found that histone methylation by KDM4A was important in mediating a positive feedback loop in squamous cell carcinoma (SCC) that enabled the transcription factor complex AP1 (activating protein 1) to induce the expression of its component transcription factors, JUN and FOSL1, implicated in metastatic cancer. Depletion of KDM4A suppressed invasion by SCC cells in vitro and decreased the incidence of lymph node metastasis of SCC tumors in a mouse cancer model. The abundance of KDM4A correlated with that of JUN and FOSL1 in human primary SCC and metastatic SCC tissue. The findings suggest that KDM4A could be targeted to prevent metastasis of SCC.

Citation: X. Ding, H. Pan, J. Li, Q. Zhong, X. Chen, S. M. Dry, C.-Y. Wang, Epigenetic Activation of AP1 Promotes Squamous Cell Carcinoma Metastasis. Sci. Signal. 6, ra28 (2013).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Histone Demethylases Set the Stage for Cancer Metastasis.
J. Cao and Q. Yan (2013)
Science Signaling 6, pe15
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882