Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 7 May 2013
Vol. 6, Issue 274, p. ra33
[DOI: 10.1126/scisignal.2003598]


Editor's Summary

Flies Need Nuclear Calcium to Remember
Memory formation is a complex process, and the formation of long-term memories requires changes in gene expression to persistently adapt the neuronal circuitry. The ability to create lasting memories of aversive experiences associated with smells likely provides a survival advantage. Weislogel et al. used fruit flies with genetically encoded calcium sensors and proteins that interfered specifically with the nuclear, but not cytosolic, calcium signals to show in vivo that nuclear calcium was specifically required for changes in long-term olfactory avoidance memory formation, but not for other forms of olfactory avoidance memories that do not require gene expression. This study provides a demonstration of the signals required for lasting memory formation in vivo.

Citation: J.-M. Weislogel, C. P. Bengtson, M. K. Müller, J. N. Hörtzsch, M. Bujard, C. M. Schuster, H. Bading, Requirement for Nuclear Calcium Signaling in Drosophila Long-Term Memory. Sci. Signal. 6, ra33 (2013).

Read the Full Text

Science Signaling Podcast: 7 May 2013.
H. Bading and A. M. VanHook (2013)
Science Signaling 6, pc12
   Abstract »    Full Text »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882