Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 23 July 2013
Vol. 6, Issue 285, p. ra62
[DOI: 10.1126/scisignal.2003947]

RESEARCH ARTICLES

Editor's Summary

Imaging Receptor Crosstalk
Natural killer (NK) cells mediate the immune response to virally infected cells and tumor cells, and their activation state depends on the integration of signals from multiple activating and inhibitory cell-surface receptors. The limitations of light microscopy have prevented a clear understanding of the distribution of these receptors, so Pageon et al. used superresolution fluorescence microscopy to view the organization of the inhibitory receptor KIR2DL1 on the surface of human NK cells. KIR2DL1 was constitutively organized in nanometer-scale clusters that became smaller and denser when cells were treated with a KIR2DL1-specific antibody; unexpectedly however, a similar redistribution of KIR2DL1 occurred in response to engagement of the activating receptor NKG2D. Together, these data reveal crosstalk between activating and inhibitory receptors that may have important effects on NK cell function.

Citation: S. V. Pageon, S.-P. Cordoba, D. M. Owen, S. M. Rothery, A. Oszmiana, D. M. Davis, Superresolution Microscopy Reveals Nanometer-Scale Reorganization of Inhibitory Natural Killer Cell Receptors upon Activation of NKG2D. Sci. Signal. 6, ra62 (2013).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Science Signaling Podcast: 23 July 2013.
D. M. Davis and A. M. VanHook (2013)
Science Signaling 6, pc19
   Abstract »    Full Text »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882