Sci. Signal., 3 September 2013
No Eating, No MatingOrganisms in their natural environment are exposed to multiple signals simultaneously and must coordinate their responses to these stimuli appropriately. Mating in the yeast Saccharomyces cerevisiae is initiated by the binding of pheromone to a cell-surface receptor that activates a heterotrimeric G protein containing Gpa1. Clement et al. found that mating responses were inhibited in yeast grown under conditions of limited glucose availability, which correlated with an increase in the phosphorylation of Gpa1. Experiments with mutant yeast strains showed that Gpa1 was a substrate of the same kinases and phosphatase that regulate the kinase Snf1, which is the homolog of the mammalian nutrient-sensing enzyme AMPK. Thus, regulation of Gpa1 by both nutrients and pheromone ensures that yeast mate only when there are sufficient nutrients available.
Citation: S. T. Clement, G. Dixit, H. G. Dohlman, Regulation of Yeast G Protein Signaling by the Kinases That Activate the AMPK Homolog Snf1. Sci. Signal. 6, ra78 (2013).
The editors suggest the following Related Resources on Science sites:
In Science Signaling
In Science Magazine
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882