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Sci. Signal., 15 October 2013
Vol. 6, Issue 297, p. ra91
Setting a Limit on Antibody Production
How much and what type of antibody a B cell produces depend on the strength and type of the stimulating signal. Engagement of the B cell antigen receptor (BCR) stimulates the phospholipase –dependent production of the second messenger diacylglycerol (DAG). In turn, DAG activates Ras–extracellular signal–regulated kinase (Ras-ERK) signaling, which is required for B cell proliferation and survival, as well as for their differentiation into antibody-secreting plasma cells. Wheeler et al. found that B cells deficient in the isoform of DAG kinase (DGK), which phosphorylates DAG to attenuate its signaling, exhibited enhanced ERK activation and antibody production in vitro. Furthermore, mice deficient in DGK produced more antibodies than did wild-type mice in response to immunization with various antigens, suggesting that DGK limits BCR-dependent ERK signaling and antibody production.
Citation: M. L. Wheeler, M. B. Dong, R. Brink, X.-P. Zhong, A. L. DeFranco, Diacylglycerol Kinase Limits B Cell Antigen Receptor–Dependent Activation of ERK Signaling to Inhibit Early Antibody Responses. Sci. Signal.6, ra91 (2013).
Annemiek B. van Spriel, Sandra de Keijzer, Alie van der Schaaf, Kate H. Gartlan, Mariam Sofi, Amanda Light, Peter C. Linssen, Jan B. Boezeman, Malou Zuidscherwoude, Inge Reinieren-Beeren, Alessandra Cambi, Fabienne Mackay, David M. Tarlinton, Carl G. Figdor, and Mark D. Wright (13 November 2012) Sci. Signal.5 (250), ra82.
[DOI: 10.1126/scisignal.2003113] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »
Wanli Liu, Elizabeth Chen, Xing Wang Zhao, Zheng Peng Wan, Yi Ren Gao, Angel Davey, Eric Huang, Lijia Zhang, Jillian Crocetti, Gabriel Sandoval, M. Gordon Joyce, Carrie Miceli, Jan Lukszo, L. Aravind, Wojciech Swat, Joseph Brzostowski, and Susan K. Pierce (31 July 2012) Sci. Signal.5 (235), ra54.
[DOI: 10.1126/scisignal.2002820] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »