Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Sci. Signal., 3 December 2013
Vol. 6, Issue 304, p. ra104
The vascular endothelial growth factor receptor-2 (VEGFR-2) promotes the formation of new blood vessels in a process called angiogenesis. Hartsough et al. identified a key lysine residue in VEGFR-2 that underwent methylation, a posttranslational modification that enhanced the activity of this receptor. Cells expressing a form of VEGFR-2 that could not be methylated at this residue formed smaller tumors in mice, and developing zebrafish expressing this mutant form of VEGFR-2 showed reduced blood vessel formation. Thus, preventing the methylation of VEGFR-2 could be a strategy to limit angiogenesis and thus the growth of tumors.
Citation: E. J. Hartsough, R. D. Meyer, V. Chitalia, Y. Jiang, V. E. Marquez, I. V. Zhdanova, J. Weinberg, C. E. Costello, N. Rahimi, Lysine Methylation Promotes VEGFR-2 Activation and Angiogenesis. Sci. Signal.6, ra104 (2013).