Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 17 December 2013
Vol. 6, Issue 306, p. ra110
[DOI: 10.1126/scisignal.2004273]


Editor's Summary

Determining T Cell Fate
T cell receptor (TCR)–dependent activation of the transcription factor nuclear factor {kappa}B (NF-{kappa}B) requires a complex containing the adaptor protein CARMA1, which results in the downstream activation of the inhibitor of NF-{kappa}B (I{kappa}B) kinase (IKK) complex, including IKKβ. Blonska et al. showed that CARMA1 and IKKβ perform double duty in also mediating the TCR-dependent activation of c-Maf, a transcription factor required for the development of T follicular helper (TFH) cells, which help B cells to make antibodies against various antigens. CARMA1 and IKKβ did not affect the abundance of c-Maf in TCR-activated T cells but were required for its phosphorylation and translocation to the nucleus in an NF-{kappa}B–independent manner. Immunized mice deficient in either CARMA1 or IKKβ generated decreased numbers of TFH cells compared to immunized wild-type mice and had defective antibody production by B cells. Together, these data suggest that CARMA1 and IKKβ act outside the NF-{kappa}B signaling axis to help determine T cell fate.

Citation: M. Blonska, D. Joo, R. I. Nurieva, X. Zhao, P. Chiao, S.-C. Sun, C. Dong, X. Lin, Activation of the Transcription Factor c-Maf in T Cells Is Dependent on the CARMA1-IKKβ Signaling Cascade. Sci. Signal. 6, ra110 (2013).

Read the Full Text

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882