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Science 287 (5455): 982-985

Copyright © 2000 by the American Association for the Advancement of Science

Signals to Move Cells

Lodewijk V. Dekker and Anthony W. Segal

Although there is lots of information about chemoattractant receptors and their ligands, which direct the locomotion of phagocytic cells of the immune system, there are still missing pieces to the signaling pathways that turn receptor activation into directed migration. In a Perspective, Dekker and Segal discuss new findings (Li, Sasaki, Hirsch) that slot the gamma isoform of PI 3-kinase into the signaling picture. They show that the p110g catalytic subunit of PI 3-kinase g is involved both in the migration of neutrophils and macrophages and the activation of T cells.

The authors are at the Centre for Molecular Medicine, University College London, 5 University Street, London WC1E 6JJ, UK. E-mail: rmhalvd{at}

Tyrosine kinase Btk regulates E-selectin-mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) {gamma}2 and PI3K{gamma} pathways.
H. Mueller, A. Stadtmann, H. Van Aken, E. Hirsch, D. Wang, K. Ley, and A. Zarbock (2010)
Blood 115, 3118-3127
   Abstract »    Full Text »    PDF »
Modeling the Role of Homologous Receptor Desensitization in Cell Gradient Sensing.
F. Lin and E. C. Butcher (2008)
J. Immunol. 181, 8335-8343
   Abstract »    Full Text »    PDF »
TLR4 Facilitates Translocation of Bacteria across Renal Collecting Duct Cells.
C. Chassin, S. Vimont, F. Cluzeaud, M. Bens, J.-M. Goujon, B. Fernandez, A. Hertig, E. Rondeau, G. Arlet, M. W. Hornef, et al. (2008)
J. Am. Soc. Nephrol. 19, 2364-2374
   Abstract »    Full Text »    PDF »
Leukocyte PI3K{gamma} and PI3K{delta} have temporally distinct roles for leukocyte recruitment in vivo.
L. Liu, K. D. Puri, J. M. Penninger, and P. Kubes (2007)
Blood 110, 1191-1198
   Abstract »    Full Text »    PDF »
Bursting with PIP3.
D. A. Fruman (2005)
Blood 106, 1139-1140
   Full Text »    PDF »
Vav Activation and Function as a Rac Guanine Nucleotide Exchange Factor in Macrophage Colony-Stimulating Factor-Induced Macrophage Chemotaxis.
V. Vedham, H. Phee, and K. M. Coggeshall (2005)
Mol. Cell. Biol. 25, 4211-4220
   Abstract »    Full Text »    PDF »
PHR1, a PH Domain-Containing Protein Expressed in Primary Sensory Neurons.
S. Xu, Y. Wang, H. Zhao, L. Zhang, W. Xiong, K.-W. Yau, H. Hiel, E. Glowatzki, D. K. Ryugo, and D. Valle (2004)
Mol. Cell. Biol. 24, 9137-9151
   Abstract »    Full Text »    PDF »
Early signaling events involved in the entry of Rickettsia conorii into mammalian cells.
J. J. Martinez and P. Cossart (2004)
J. Cell Sci. 117, 5097-5106
   Abstract »    Full Text »    PDF »
The Chemoattractants, IL-8 and Formyl-Methionyl-Leucyl-Phenylalanine, Regulate Granulocyte Colony-Stimulating Factor Signaling by Inducing Suppressor of Cytokine Signaling-1 Expression.
N. J. Stevenson, S. Haan, A. E. McClurg, M. J. McGrattan, M. A. Armstrong, P. C. Heinrich, and J. A. Johnston (2004)
J. Immunol. 173, 3243-3249
   Abstract »    Full Text »    PDF »
An Annexin 1 N-Terminal Peptide Activates Leukocytes by Triggering Different Members of the Formyl Peptide Receptor Family.
S. Ernst, C. Lange, A. Wilbers, V. Goebeler, V. Gerke, and U. Rescher (2004)
J. Immunol. 172, 7669-7676
   Abstract »    Full Text »    PDF »
Urokinase-Type Plasminogen Activator Potentiates Lipopolysaccharide-Induced Neutrophil Activation.
E. Abraham, M. R. Gyetko, K. Kuhn, J. Arcaroli, D. Strassheim, J. S. Park, S. Shetty, and S. Idell (2003)
J. Immunol. 170, 5644-5651
   Abstract »    Full Text »    PDF »
Akt Phosphorylates p47phox and Mediates Respiratory Burst Activity in Human Neutrophils.
Q. Chen, D. W. Powell, M. J. Rane, S. Singh, W. Butt, J. B. Klein, and K. R. McLeish (2003)
J. Immunol. 170, 5302-5308
   Abstract »    Full Text »    PDF »
Gradient Steepness Influences the Pathfinding Decisions of Neuronal Growth Cones In Vivo.
C. M. Isbister, P. J. Mackenzie, K. C. W. To, and T. P. O'Connor (2003)
J. Neurosci. 23, 193-202
   Abstract »    Full Text »    PDF »
Electrical cues regulate the orientation and frequency of cell division and the rate of wound healing in vivo.
B. Song, M. Zhao, J. V. Forrester, and C. D. McCaig (2002)
PNAS 99, 13577-13582
   Abstract »    Full Text »    PDF »
15-Deoxyspergualin Inhibits Akt Kinase Activation and Phosphatidylcholine Synthesis.
M. Kawada, T. Masuda, M. Ishizuka, and T. Takeuchi (2002)
J. Biol. Chem. 277, 27765-27771
   Abstract »    Full Text »    PDF »
Increased responsiveness of murine eosinophils to MIP-1{beta} (CCL4) and TCA-3 (CCL1) is mediated by their specific receptors, CCR5 and CCR8.
S. H. P. Oliveira, S. Lira, C. Martinez-A, M. Wiekowski, L. Sullivan, and N. W. Lukacs (2002)
J. Leukoc. Biol. 71, 1019-1025
   Abstract »    Full Text »    PDF »
Neutrophils lacking phosphoinositide 3-kinase {gamma} show loss of directionality during N-formyl-Met-Leu-Phe-induced chemotaxis.
M. Hannigan, L. Zhan, Z. Li, Y. Ai, D. Wu, and C.-K. Huang (2002)
PNAS 99, 3603-3608
   Abstract »    Full Text »    PDF »
Involvement of Phosphoinositide 3-Kinases in Neutrophil Activation and the Development of Acute Lung Injury.
H.-K. Yum, J. Arcaroli, J. Kupfner, R. Shenkar, J. M. Penninger, T. Sasaki, K.-Y. Yang, J. S. Park, and E. Abraham (2001)
J. Immunol. 167, 6601-6608
   Abstract »    Full Text »    PDF »
Activation of class IA PI3K stimulates DNA synthesis in human airway smooth muscle cells.
V. P. Krymskaya, A. J. Ammit, R. K. Hoffman, A. J. Eszterhas, and R. A. Panettieri Jr. (2001)
Am J Physiol Lung Cell Mol Physiol 280, L1009-L1018
   Abstract »    Full Text »    PDF »
The High Mobility Group (Hmg) Boxes of the Nuclear Protein Hmg1 Induce Chemotaxis and Cytoskeleton Reorganization in Rat Smooth Muscle Cells.
B. Degryse, T. Bonaldi, P. Scaffidi, S. Muller, M. Resnati, F. Sanvito, G. Arrigoni, and M. E. Bianchi (2001)
J. Cell Biol. 152, 1197-1206
   Abstract »    Full Text »    PDF »
Platelet-released phospholipids link haemostasis and angiogenesis.
D. English, J. G.N. Garcia, and D.N. Brindley (2001)
Cardiovasc Res 49, 588-599
   Abstract »    Full Text »    PDF »
Type 1 pilus-mediated bacterial invasion of bladder epithelial cells.
J. J. Martinez, M. A. Mulvey, J. D. Schilling, J. S. Pinkner, and S. J. Hultgren (2000)
EMBO J. 19, 2803-2812
   Abstract »    Full Text »    PDF »
N-Formyl Peptide Receptor Ligation Induces Rac-dependent Actin Reorganization through Gbeta gamma Subunits and Class Ia Phosphoinositide 3-Kinases.
B. Belisle and A. Abo (2000)
J. Biol. Chem. 275, 26225-26232
   Abstract »    Full Text »    PDF »
Role of Phosphoinositide 3-Kinase in Monocyte Recruitment under Flow Conditions.
R. E. Gerszten, E. B. Friedrich, T. Matsui, R. R. Hung, L. Li, T. Force, and A. Rosenzweig (2001)
J. Biol. Chem. 276, 26846-26851
   Abstract »    Full Text »    PDF »
Activation of type II alveolar epithelial cells during acute endotoxemia.
V. R. Sunil, A. J. Connor, Y. Guo, J. D. Laskin, and D. L. Laskin (2002)
Am J Physiol Lung Cell Mol Physiol 282, L872-L880
   Abstract »    Full Text »    PDF »

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