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Science 287 (5455): 982-985

Copyright © 2000 by the American Association for the Advancement of Science

SIGNAL TRANSDUCTION:
Signals to Move Cells

Lodewijk V. Dekker and Anthony W. Segal

Although there is lots of information about chemoattractant receptors and their ligands, which direct the locomotion of phagocytic cells of the immune system, there are still missing pieces to the signaling pathways that turn receptor activation into directed migration. In a Perspective, Dekker and Segal discuss new findings (Li, Sasaki, Hirsch) that slot the gamma isoform of PI 3-kinase into the signaling picture. They show that the p110g catalytic subunit of PI 3-kinase g is involved both in the migration of neutrophils and macrophages and the activation of T cells.

The authors are at the Centre for Molecular Medicine, University College London, 5 University Street, London WC1E 6JJ, UK. E-mail: rmhalvd{at}ucl.ac.uk

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