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Science 292 (5519): 1080-1081

Copyright © 2001 by the American Association for the Advancement of Science

Legs, Eyes, or Wings--Selectors and Signals Make the Difference

Markus Affolter and Richard Mann

How do the cells that give rise to structures such as the eye, wing, and leg in the developing fruit fly know where they are and what to do? As Affolter and Mann explain in their Perspective, it now seems that a selector transcription factor complex and a signaling effector protein interact together on a DNA enhancer sequence, switching on the appropriate set of target genes that then direct development of the appropriate structure.

M. Affolter is with the Biozentrum der Universitat Basel, Abteilung Zellbiologie, Basel CH-4056, Switzerland. E-mail: R. Mann is in the Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA. E-mail:

Branching Morphogenesis: From Cells to Organs and Back.
A. Ochoa-Espinosa and M. Affolter (2012)
Cold Spring Harb Perspect Biol 4, a008243
   Abstract »    Full Text »    PDF »
Cross-regulatory protein-protein interactions between Hox and Pax transcription factors.
S. Plaza, F. Prince, Y. Adachi, C. Punzo, D. L. Cribbs, and W. J. Gehring (2008)
PNAS 105, 13439-13444
   Abstract »    Full Text »    PDF »
Misexpression Screen in Drosophila melanogaster Aiming to Reveal Novel Factors Involved in Formation of Body Parts.
N. C. Grieder, I. Charlafti, U. Kloter, H. Jackle, U. Schafer, and W. J. Gehring (2007)
Genetics 175, 1707-1718
   Abstract »    Full Text »    PDF »
Involvement of winged eye encoding a chromatin-associated bromo-adjacent homology domain protein in disc specification.
T. Katsuyama, T. Sugawara, M. Tatsumi, Y. Oshima, W. J. Gehring, T. Aigaki, and S. Kurata (2005)
PNAS 102, 15918-15923
   Abstract »    Full Text »    PDF »
Pointed regulates an eye-specific transcriptional enhancer in the Drosophila hedgehog gene, which is required for the movement of the morphogenetic furrow.
E. M. Rogers, C. A. Brennan, N. T. Mortimer, S. Cook, A. R. Morris, and K. Moses (2005)
Development 132, 4833-4843
   Abstract »    Full Text »    PDF »
Peak levels of BMP in the Drosophila embryo control target genes by a feed-forward mechanism.
M. Xu, N. Kirov, and C. Rushlow (2005)
Development 132, 1637-1647
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Downstream-of-FGFR Is a Fibroblast Growth Factor-Specific Scaffolding Protein and Recruits Corkscrew upon Receptor Activation.
V. Petit, U. Nussbaumer, C. Dossenbach, and M. Affolter (2004)
Mol. Cell. Biol. 24, 3769-3781
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Initiating Hox gene expression: in the early chick neural tube differential sensitivity to FGF and RA signaling subdivides the HoxB genes in two distinct groups.
S. Bel-Vialar, N. Itasaki, and R. Krumlauf (2003)
Development 129, 5103-5115
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Genetic requirements of vestigial in the regulation of Drosophila wing development.
L. A. Baena-Lopez and A. Garcia-Bellido (2003)
Development 130, 197-208
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The Drosophila gap junction channel gene innexin 2 controls foregut development in response to Wingless signalling.
R. Bauer, C. Lehmann, B. Fuss, F. Eckardt, and M. Hoch (2002)
J. Cell Sci. 115, 1859-1867
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Krox20 and kreisler co-operate in the transcriptional control of segmental expression of Hoxb3 in the developing hindbrain.
M. Manzanares, J. Nardelli, P. Gilardi-Hebenstreit, H. Marshall, F. Giudicelli, M. T. Martinez-Pastor, R. Krumlauf, and P. Charnay (2002)
EMBO J. 21, 365-376
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Critical Roles of a Cyclic AMP Responsive Element and an E-box in Regulation of Mouse Renin Gene Expression.
L. Pan, T. A. Black, Q. Shi, C. A. Jones, N. Petrovic, J. Loudon, C. Kane, C. D. Sigmund, and K. W. Gross (2001)
J. Biol. Chem. 276, 45530-45538
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