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DEVELOPMENT: Legs, Eyes, or Wings--Selectors and Signals Make the Difference
Markus Affolter and Richard Mann
How do the cells that give rise to structures such as the eye, wing, and leg in the developing fruit fly know where they are and what to do? As Affolter and Mann explain in their Perspective, it now seems that a selector transcription factor complex and a signaling effector protein interact together on a DNA enhancer sequence, switching on the appropriate set of target genes that then direct development of the appropriate structure.
M. Affolter is with the Biozentrum der Universitat Basel, Abteilung Zellbiologie, Basel CH-4056, Switzerland. E-mail: email@example.com R. Mann is in the Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA. E-mail: firstname.lastname@example.org.
The editors suggest the following Related Resources on Science sites:
In Science Magazine
Kirsten A. Guss, Craig E. Nelson, Angela Hudson, Mary Ellen Kraus, and Sean B. Carroll (11 May 2001) Science292 (5519), 1164.
[DOI: 10.1126/science.1058312] |Abstract »|Full Text »|PDF »
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