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Science 295 (5562): 2029-2031

Copyright © 2002 by the American Association for the Advancement of Science

A Perfect Mismatch

Klas Kärre

For patients with leukemia that is refractory to chemotherapy, bone marrow or stem cell transplantation is often the only hope. In his Perspective, Kärre discusses important new findings (Ruggeri et al.) revealing that a favorable mismatch in HLA molecules between donor and recipient tissues enables natural killer cells in the graft to reduce host rejection of the transplant while promoting attack of residual leukemia cells, thus increasing the likelihood that the transplant will succeed.

The author is at the Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden.

The role of KIR genes and their cognate HLA class I ligands in childhood acute lymphoblastic leukemia.
A. J. de Smith, K. M. Walsh, M. B. Ladner, S. Zhang, C. Xiao, F. Cohen, T. B. Moore, A. P. Chokkalingam, C. Metayer, P. A. Buffler, et al. (2014)
Blood 123, 2497-2503
   Abstract »    Full Text »    PDF »
NK cells expressing inhibitory KIR for non-self-ligands remain tolerant in HLA-matched sibling stem cell transplantation.
A. T. Bjorklund, M. Schaffer, C. Fauriat, O. Ringden, M. Remberger, C. Hammarstedt, A. J. Barrett, P. Ljungman, H.-G. Ljunggren, and K.-J. Malmberg (2010)
Blood 115, 2686-2694
   Abstract »    Full Text »    PDF »
Estimation of the Size of the Alloreactive NK Cell Repertoire: Studies in Individuals Homozygous for the Group A KIR Haplotype.
C. Fauriat, S. Andersson, A. T. Bjorklund, M. Carlsten, M. Schaffer, N. K. Bjorkstrom, B. C. Baumann, J. Michaelsson, H.-G. Ljunggren, and K.-J. Malmberg (2008)
J. Immunol. 181, 6010-6019
   Abstract »    Full Text »    PDF »
Donor natural killer cell allorecognition of missing self in haploidentical hematopoietic transplantation for acute myeloid leukemia: challenging its predictive value..
L. Ruggeri, A. Mancusi, M. Capanni, E. Urbani, A. Carotti, T. Aloisi, M. Stern, D. Pende, K. Perruccio, E. Burchielli, et al. (2007)
Blood 110, 433-440
   Abstract »    Full Text »    PDF »
NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs.
C. Borg, A. Jalil, D. Laderach, K. Maruyama, H. Wakasugi, S. Charrier, B. Ryffel, A. Cambi, C. Figdor, W. Vainchenker, et al. (2004)
Blood 104, 3267-3275
   Abstract »    Full Text »    PDF »
Determinants of Antileukemia Effects of Allogeneic NK Cells.
W. Leung, R. Iyengar, V. Turner, P. Lang, P. Bader, P. Conn, D. Niethammer, and R. Handgretinger (2004)
J. Immunol. 172, 644-650
   Abstract »    Full Text »    PDF »
Survival advantage with KIR ligand incompatibility in hematopoietic stem cell transplantation from unrelated donors.
S. Giebel, F. Locatelli, T. Lamparelli, A. Velardi, S. Davies, G. Frumento, R. Maccario, F. Bonetti, J. Wojnar, M. Martinetti, et al. (2003)
Blood 102, 814-819
   Abstract »    Full Text »    PDF »
NK Cell Activity During Human Cytomegalovirus Infection Is Dominated by US2-11-Mediated HLA Class I Down-Regulation.
C. S. Falk, M. Mach, D. J. Schendel, E. H. Weiss, I. Hilgert, and G. Hahn (2002)
J. Immunol. 169, 3257-3266
   Abstract »    Full Text »    PDF »

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