Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 296 (5567): 479-481

Copyright © 2002 by the American Association for the Advancement of Science

Proteasome Parts at Gene Promoters

Søren Ottosen, Francisco J. Herrera, Steven J. Triezenberg

The proteasome is a garbage disposal unit in eukaryotic cells that degrades proteins tagged with ubiquitin molecules. In their Perspective, Ottosen and colleagues discuss new findings (Gonzalez et al.) revealing that certain components of the proteasome may be involved in processes other than protein degradation. Six ATPases in the base section of the 19S proteasomal subcomplex are recruited to sites of gene activation, suggesting that they may be involved in transcription.

The authors are in the Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA. E-mail: triezenb{at}

Cks1 Enhances Transcription Efficiency at the GAL1 Locus by Linking the Paf1 Complex to the 19S Proteasome.
Y.-R. Pan, M. Sun, J. Wohlschlegel, and S. I. Reed (2013)
Eukaryot. Cell 12, 1192-1201
   Abstract »    Full Text »    PDF »
The Birt-Hogg-Dube tumor suppressor Folliculin negatively regulates ribosomal RNA synthesis.
K. Gaur, J. Li, D. Wang, P. Dutta, S.-J. Yan, A. Tsurumi, H. Land, G. Wu, and W. X. Li (2013)
Hum. Mol. Genet. 22, 284-299
   Abstract »    Full Text »    PDF »
Characterization of the proteasome interaction with the Sec61 channel in the endoplasmic reticulum.
W. Ng, T. Sergeyenko, N. Zeng, J. D. Brown, and K. Romisch (2007)
J. Cell Sci. 120, 682-691
   Abstract »    Full Text »    PDF »
Widespread, but Non-identical, Association of Proteasomal 19 and 20 S Proteins with Yeast Chromatin.
D. Sikder, S. A. Johnston, and T. Kodadek (2006)
J. Biol. Chem. 281, 27346-27355
   Abstract »    Full Text »    PDF »
Cross Talk in Hormonally Regulated Gene Transcription through Induction of Estrogen Receptor Ubiquitylation.
M. Luo, M. Koh, J. Feng, Q. Wu, and P. Melamed (2005)
Mol. Cell. Biol. 25, 7386-7398
   Abstract »    Full Text »    PDF »
Functional and Physical Interaction of the Human ARF Tumor Suppressor with Tat-binding Protein-1.
A. Pollice, V. Nasti, R. Ronca, M. Vivo, M. L. Iacono, R. Calogero, V. Calabro, and G. La Mantia (2004)
J. Biol. Chem. 279, 6345-6353
   Abstract »    Full Text »    PDF »
The Co-repressor Hairless Protects ROR{alpha} Orphan Nuclear Receptor from Proteasome-mediated Degradation.
A. N. Moraitis and V. Giguere (2003)
J. Biol. Chem. 278, 52511-52518
   Abstract »    Full Text »    PDF »
Phosphorylation of Kruppel-like factor 5 (KLF5/IKLF) at the CBP interaction region enhances its transactivation function.
Z. Zhang and C. T. Teng (2003)
Nucleic Acids Res. 31, 2196-2208
   Abstract »    Full Text »    PDF »
Involvement of Proteasome in the Dynamic Assembly of the Androgen Receptor Transcription Complex.
Z. Kang, A. Pirskanen, O. A. Janne, and J. J. Palvimo (2002)
J. Biol. Chem. 277, 48366-48371
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882