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Science 296 (5567): 479-481

Copyright © 2002 by the American Association for the Advancement of Science

TRANSCRIPTION:
Proteasome Parts at Gene Promoters

Søren Ottosen, Francisco J. Herrera, Steven J. Triezenberg

The proteasome is a garbage disposal unit in eukaryotic cells that degrades proteins tagged with ubiquitin molecules. In their Perspective, Ottosen and colleagues discuss new findings (Gonzalez et al.) revealing that certain components of the proteasome may be involved in processes other than protein degradation. Six ATPases in the base section of the 19S proteasomal subcomplex are recruited to sites of gene activation, suggesting that they may be involved in transcription.


The authors are in the Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA. E-mail: triezenb{at}msu.edu


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