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Science 296 (5571): 1248-1249

Copyright © 2002 by the American Association for the Advancement of Science

Also see the archival list of Science's Compass: Enhanced Perspectives

Enhanced: A Pathogen Receptor on Natural Killer Cells

Eric Vivier and Christine A. Biron

Natural killer (NK) cells of the innate immune system lack receptors tailored, through genetic reshuffling, to recognize an enormous array of antigens. However, they are readily able to recognize bacterial, viral, and tumor cell molecules. In their Perspective, Vivier and Biron discuss new work (Arase et al.) that identifies an activating Ly49 receptor on mouse NK cells that recognizes a viral protein and protects mice against MCMV infection.

E. Vivier is at the Centre d'Immunologie de Marseille-Luminy, INSERM-CNRS-Universite Méditerranée, Marseille, France. E-mail: vivier{at} C. A. Biron is in the Division of Biology and Medicine, Brown University, Providence, RI 02912, USA. E-mail: christine_biron{at}

Expression of ICP0 Is Sufficient to Trigger Natural Killer Cell Recognition of Herpes Simplex Virus--Infected Cells by Natural Cytotoxicity Receptors.
S. E. Chisholm, K. Howard, M. Vales Gomez, and H. T. Reyburn (2007)
The Journal of Infectious Disease 195, 1160-1168
   Abstract »    Full Text »    PDF »
Recognition of Vaccinia Virus-Infected Cells by Human Natural Killer Cells Depends on Natural Cytotoxicity Receptors.
S. E. Chisholm and H. T. Reyburn (2006)
J. Virol. 80, 2225-2233
   Abstract »    Full Text »    PDF »
Natural-killer cells and dendritic cells: "l'union fait la force".
T. Walzer, M. Dalod, S. H. Robbins, L. Zitvogel, and E. Vivier (2005)
Blood 106, 2252-2258
   Abstract »    Full Text »    PDF »
Origin and Fate of Lymphocytic Choriomeningitis Virus-Specific CD8+ T Cells Coexpressing the Inhibitory NK Cell Receptor Ly49G2.
C. D. Peacock and R. M. Welsh (2004)
J. Immunol. 173, 478-484
   Abstract »    Full Text »    PDF »
Upregulation of Major Histocompatibility Complex Class I on Liver Cells by Hepatitis C Virus Core Protein via p53 and TAP1 Impairs Natural Killer Cell Cytotoxicity.
K. Herzer, C. S. Falk, J. Encke, S. T. Eichhorst, A. Ulsenheimer, B. Seliger, and P. H. Krammer (2003)
J. Virol. 77, 8299-8309
   Abstract »    Full Text »    PDF »
DNA Is a Target of the Photodynamic Effects Elicited in A2E-Laden RPE by Blue-Light Illumination.
J. R. Sparrow, J. Zhou, and B. Cai (2003)
Invest. Ophthalmol. Vis. Sci. 44, 2245-2251
   Abstract »    Full Text »    PDF »
Cutting Edge: Susceptibility to Psoriatic Arthritis: Influence of Activating Killer Ig-Like Receptor Genes in the Absence of Specific HLA-C Alleles.
M. P. Martin, G. Nelson, J.-H. Lee, F. Pellett, X. Gao, J. Wade, M. J. Wilson, J. Trowsdale, D. Gladman, and M. Carrington (2002)
J. Immunol. 169, 2818-2822
   Abstract »    Full Text »    PDF »

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