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IMMUNOLOGY: Enhanced: A Pathogen Receptor on Natural Killer Cells
Eric Vivier and Christine A. Biron
Natural killer (NK) cells of the innate immune system lack receptors tailored, through genetic reshuffling, to recognize an enormous array of antigens. However, they are readily able to recognize bacterial, viral, and tumor cell molecules. In their Perspective, Vivier and Biron discuss new work (Arase et al.) that identifies an activating Ly49 receptor on mouse NK cells that recognizes a viral protein and protects mice against MCMV infection.
E. Vivier is at the Centre d'Immunologie de Marseille-Luminy, INSERM-CNRS-Universite Méditerranée, Marseille, France. E-mail: vivier{at}ciml.univ-mrs.fr C. A. Biron is in the Division of Biology and Medicine, Brown University, Providence, RI 02912, USA. E-mail: christine_biron{at}brown.edu
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REPORTS
Hisashi Arase, Edward S. Mocarski, Ann E. Campbell, Ann B. Hill, and Lewis L. Lanier (17 May 2002) Science296 (5571), 1323.
[DOI: 10.1126/science.1070884] |Abstract »|Full Text »|PDF »|Supplemental Data »
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