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Science 296 (5571): 1250-1251

Copyright © 2002 by the American Association for the Advancement of Science

Genomic Priorities in Aging

Paul Hasty and Jan Vijg

Many theories of aging have been proposed, but one of the most enduring is that expounding accumulated damage to the DNA as the root cause. In their Perspective, Hasty and Vijg comment on recent findings (de Boer et al.) in a mouse model of a human disease that point to imperfect repair of DNA damage over a lifetime as an important contributor to the cellular deterioration associated with aging.

P. Hasty is in the Department of Molecular Medicine and J. Vijg is in the Department of Physiology and Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX 78245, USA. J. Vijg is also at the Geriatric Research Education and Clinical Center, South Texas Veterans Health Care System, San Antonio, TX 78229, USA. E-mail: hastye{at}, vijg{at}

Longevity and resistance to stress correlate with DNA repair capacity in Caenorhabditis elegans.
M. Hyun, J. Lee, K. Lee, A. May, V. A. Bohr, and B. Ahn (2008)
Nucleic Acids Res. 36, 1380-1389
   Abstract »    Full Text »    PDF »
Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system.
F. Madia, C. Gattazzo, M. Wei, P. Fabrizio, W. C. Burhans, M. Weinberger, A. Galbani, J. R. Smith, C. Nguyen, S. Huey, et al. (2008)
J. Cell Biol. 180, 67-81
   Abstract »    Full Text »    PDF »
DNA damage and osmotic regulation in the kidney.
N. I. Dmitrieva, M. B. Burg, and J. D. Ferraris (2005)
Am J Physiol Renal Physiol 289, F2-F7
   Abstract »    Full Text »    PDF »

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