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Science 296 (5574): 1815-1817

Copyright © 2002 by the American Association for the Advancement of Science

T Cell Activation in Six Dimensions

Ulrich H. von Andrian

What are T cells doing deep within the recesses of the lymph nodes they inhabit? In his Perspective, von Andrian discusses the findings of several studies that use two-photon and confocal microscopy to illuminate (literally) the private lives of T cells.

The author is at the Center for Blood Research, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA. E-mail: uva{at}

Tomographic Fluorescence Mapping of Tumor Targets.
X. Montet, V. Ntziachristos, J. Grimm, and R. Weissleder (2005)
Cancer Res. 65, 6330-6336
   Abstract »    Full Text »    PDF »
Restricted Clonal Expression of IL-2 By Naive T Cells Reflects Differential Dynamic Interactions with Dendritic Cells.
V. Hurez, A. Saparov, A. Tousson, M. J. Fuller, T. Kubo, J. Oliver, B. T. Weaver, and C. T. Weaver (2003)
J. Exp. Med. 198, 123-132
   Abstract »    Full Text »    PDF »
Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy.
M. J. Miller, S. H. Wei, M. D. Cahalan, and I. Parker (2003)
PNAS 100, 2604-2609
   Abstract »    Full Text »    PDF »

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