βKlotho Is a Cofactor for FGF21
A recent publication by Ogawa et al. describes the relationship between fibroblast growth factor 21 (FGF21) and Klotho family proteins. βKlotho is expressed in adipocytes and not preadipocytes, permitting a differential in activity between these two stages of cellular differentiation. RNA interference experiments showed that FGF21-stimulated glucose uptake in adipocytes was inhibited when βKlotho was decreased. Moreover, when complexed with βKlotho FGFR1c or FGFR4 were able to pull down FGF21 more efficiently than either FGFR alone. Thus, βKlotho appears to serve as an essential cofactor for FGF21 activity.
Y. Ogawa, H. Kurosu, M. Yamamoto, A. Nandi, K. P. Rosenblatt, R. Goetz, A. V. Eliseenkova, M. Mohamadi, M. Kuro-o, βKlotho is required for metabolic activty of fibroblast growth factor 21. Proc. Natl. Acad. Sci. USA 104, 7432-7437 (2007). [Abstract] [Full Text]
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