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Open Forum on Cell Signaling

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Response to Topography of Cell Membranes

20 November 2000

James Keefer

Dear Konrad, There are several companies including mine, NovaScreen, that can screen multiple receptor targets on a cell and could add targets of interest. We currently have over 200 receptor and enzyme assays up and running. Our lab published the cell profile process in J. of Biomolecular Screening, Vol. 3, No. 3, 1998, entitled "Profiling Established Cell Lines as a Means to Screening Diversity", by Evelyn Good et al. A list of endogenous GPCR coupled receptors on a few cell lines is available at biomedcomp.com/GPCR.html from Agi Schonbrunn at Univ of Texas, Houston.

What's your opinion on screening using microarray/DNA technology?

Jim Keefer

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