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Open Discussion of Modeling and Computational Approaches to Cellular Signaling

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Can computational modeling of neuronal processes help to understand cellular signalling?

12 March 2004

Rainer C Spiegel

I am no expert in cellular signalling, but I have expertise in computational modeling of neuronal processes, i.e. when trying to create computational models that simulate interaction among nerve cells. I wonder whether the computational models that are typically applied to simulate neuronal processes (among them artificial neural networks, biologically inspired neural networks, compartmental models, Bayesian methods) were already applied in the cellular signalling community. If not, could these techniques assist to better understand cellular signalling? I would be grateful for any expert opinions in this regard.

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882