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E-Conference: Defining Calcium Entry Signals

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Session 3: Defining the Plasma Membrane Calcium Channels

24 May 2004

E-Conference Chairpersons

This session is focused on the main question of can we define the plasma membrane channels implicated in mediating calcium entry signals.

Specific issues include

(a) The properties of calcium channels:

How are specific conductances defined with respect to ion- selectivity, feedback regulation, and resemblance to or divergence from the "CRAC channel"?

(b) The role of known channel proteins:

Are proteins within the TRP superfamily of ion channels (including members of the TRPC, TRPV, and TRPM channel families) mediators of calcium entry signals?

(c) The assembly and organization of channels:

Are different channel subunits assembled into heteromeric functional calcium entry channels? If so, how are they assembled and how does association with regulatory elements mediate control over channel activity?

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