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E-Conference: Defining Calcium Entry Signals

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What are lipid rafts?

7 June 2004

Peter J Lockyer

Define this first Randen?

Are we talking the artifacts of cold detergent preps and cholesterol depletion, or the ms timescale clustering of lipid microdomains?

The rafting landscape is being challenged and is changing rapidly. The idea of stable lipid domains on the time-scale of SOCE is not very consistent with results from clever fluorescence-based assays of lipid microdomains.

They exist, and at least for GPI-anchored reporters, return to the same 'site' in the membrane. But these are remarkably transient events and the biochemical methods have been proved flawed.

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