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E-Conference: Defining Calcium Entry Signals

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RNAi and SOCE

7 June 2004

Peter J Lockyer

Systematic RNAi seems the way to clearly define the channel responsible for Icrac.

It's also the way to sort out the messy heterologous TRP expression data produced over more than a decade in various cell lines.

Presumably all of this is being done (probably has been already in big pharma) and the identity of ARCs can also be determined this way.

I don't keep a close enough eye on the TRP field, but there doesn't seem to have been a great deal of knockdown data presented in support of any TRP channels mediating forms of Ca entry, much still relies on overexpression. Is this a reasonable statement?

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