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E-Conference: Defining Calcium Entry Signals

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Gating of calcium entry channels

16 June 2004

Donna L Cioffi

I have a couple of questions for Jim Putney regarding the gating of SOCE channels.

Do you envisage a single gating mechanism for each different type of SOCE channel, perhaps in a cell-type specific manner?

And are there certain criteria you feel should be met in order to demonstrate that something (protein, peptide, ion, etc) is indeed part of the gating mechanism.....as opposed to simply modulating channel function?

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