Pharmacology of SOCs and ARC

17 June 2004

Donald Gill

This is a response to Trevor and Jim's discussion on the pharmacological distinctions between SOC and ARC.

2-APB may be useful but Trevor is not so sure that the lanthanides are useful in discriminating.

Another group of compounds, the 3,5-bistrifluoromethyl pyrazoles (papers by Ishikawa et al in J.Immunol and by Zitt et al, JBC) are interesting modifiers of ICRAC. We find they also modify SOCs in most cells and and also TRP channels. We are questioning whether their effects are direct or indirect, but we certainly find their potency is quite high (IC50 around 100 nM for both SOCs and TRPC channels). It might be useful for Trevor to look at these on ARC in case he hasn't already done so!