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E-Conference: Defining Calcium Entry Signals

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CRAC activity at low agonist concentrations?

18 June 2004

Trevor Shuttleworth

No, I'm afraid we have never tried agonist-induced responses in the RBL cells.

We are currently (no pun intended!) looking at responses in parotid cells in an attempt to obtain data on a "real" cell. We know the ARC channels are there, and Ca2+ entry at low concentrations of agonists is AA-dependent, but we have yet to try and record current responses to agonists - stay tuned!

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882