Principles of Cell Signaling and Biological Consequences
Group A: Discussion Question 1
31 January 2005
Soluble mitogens, such as lysophosphatidic acid (LPA) and epidermal growth factor (EGF), can both stimulate mitogen-activated protein kinase (MAPK) and proliferation in cultured cells. However, the receptors for these two growth factors are vastly different. Describe the distinct features of these two classes of receptors and their downstream signaling molecules leading to the activation of MAPK.
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882