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Principles of Cell Signaling and Biological Consequences

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Group A: Discussion Question 2

31 January 2005

Andrew Chan

The Ras family of GTP-binding proteins are molecular switches, transmitting a wide array of extracellular signals. Describe the molecular events involved in regulating the ON-OFF states of G proteins. Name two regulators of Ras that can control the equilibrium of this switch. Also, identify two genetic changes in cancer cells that have been shown to cause the constitutive activation of Ras.

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882