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Principles of Cell Signaling and Biological Consequences

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Group B: Discussion Question 2

31 January 2005

Andrew Chan

The kinetics of MAPK activation plays an important role in determining the biological outcomes of upstream signals. For example, although epidermal growth factor (EGF) stimulates a transient activation of MAPK, nerve growth factor (NGF) triggers a more sustained stimulation. Speculate on the molecular mechanisms involved in causing this divergence in signaling. Also, what are your thoughts on how this difference in MAPK activation can lead to such drastic differences in biological outcomes - proliferation verse differentiation?

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882