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Principles of Cell Signaling and Biological Consequences

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Group B: Discussion Question 3

31 January 2005

Andrew Chan

The small molecule compound, BAY43-9006, is a promising drug for treating certain forms of human cancer. Describe the major mechanism responsible for its inhibitory action. Like another kinase inhibitors, STI-571 (Gleevec), it is possible that tumors will eventually develop resistance. Name two plausible changes in cancer cells that might account for the loss of the effectiveness of these kinase inhibitors. Describe a strategy to overcome those particular forms of drug resistance.

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882