Open Forum on Cell Signaling
basal AC activity
3 May 2001
Although what Dr. Islam says is correct, several ACs have "high" basal activity even in in vitro AC assays.
Thus AC activity may not only be regulated by auto/paracrine activities or leaky GPCRs, but some ACs have high intrinsic activity before "activation".
In particular see Neilsen et al. from Dan Storm's lab. AC8 has a very high basal activity even when expression levels are accounted for.
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