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Genomes: A Platform for Signal Transduction Research?

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Cell Signalling Networks Web Tool

5 October 2001

Venky Ramakrishna

I was amazed to find an article which describes a web-based tool that allows users to map their own peptide sequences to signalling pathways. The program is called "Scansite" and is pretty straightforward to use. Of course this assumes you have used similar search/pattern finding programs before. I have recently used it and I find the search tool provides exhaustive information on signalling motifs.

Here is the citation to the article should anyone be interested:

Yaffe et al. 2001, "A motif-based profile scanning approach for genome-wide prediction of signaling pathways." Nature Biotechnology, 2001 vol. 19: 348-353.

Those who have no access to the article but still want the program should go directly to http://cansite.bidmc.harvard.edu/cantley85.phtml

I guess someone else has been thinking in the same direction and in what appears to be an important step towards globalization of informatic tools.

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882