Questions and Controversies in Zinc Signaling
Connecting Zinc to Apoptosis through BAK
22 December 2006
Nancy R Gough
An article in Molecular Cell by Moldeoveanu et al. suggests that the ability of Bak to promote mitochondrial outer membrane permeabilization is inhibited by zinc-induced dimerization. This provides a link between zinc concentrations and apoptosis, thereby expanding the roles for zinc in controlling cell physiology.
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