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Open Forum on Cell Signaling

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Cysteine Modulation in GPCR Activation

2 January 2007

Richard G. Lanzara

Increasing evidence suggests that there exists a free thiol or sulfhydryl residue within the ligand binding domain of many GPCRs (see: The importance of this residue in relation to its redox state and to receptor activation needs a larger discussion among receptor scientists and those scientists studying redox regulation.

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882