Cysteine Modulation in GPCR Activation

2 January 2007

Richard G. Lanzara

Increasing evidence suggests that there exists a free thiol or sulfhydryl residue within the ligand binding domain of many GPCRs (see:http://dx.doi.org/10.1016/j.jmgm.2006.02.008). The importance of this residue in relation to its redox state and to receptor activation needs a larger discussion among receptor scientists and those scientists studying redox regulation.