Open Forum on Cell Signaling
Cysteine Modulation in GPCR Activation
2 January 2007
Richard G. Lanzara
Increasing evidence suggests that there exists a free thiol or sulfhydryl residue within the ligand binding domain of many GPCRs (see:http://dx.doi.org/10.1016/j.jmgm.2006.02.008). The importance of this residue in relation to its redox state and to receptor activation needs a larger discussion among receptor scientists and those scientists studying redox regulation.
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