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Open Forum on Cell Signaling

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Cysteine Modulation in GPCR Activation

10 January 2007

RICHARD G LANZARA

I'm very glad that this post has attracted someone in the redox signaling field. There are a number of important questions that may only be fully answered by a combined approach from several other perspectives.

To answer your questions about this important cysteine in GPCRs, it is one of the most highly conserved residues in all GPCRs and yes, it is also known to be important for both ligand binding and receptor expression. A search on GOOGLE will give you much of this information (such as:Search: GPCR, cysteine, disulfide).

This is a fascinating area that continues to encompass many other issues in redox signaling (see Review by M. Reth) for example.

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