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Open Forum on Cell Signaling

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Mapping topology of receptors in membranes

8 March 2002

Janet M Oliver

Konrad, You opened this discussion some time ago but it would be interesting to keep this topic "alive". We use both transmission electron microscopy of membrane sheets and scanning electron microscopy of intact cells to map receptors on plasma membranes. This shows promise for giving both 2-dimensional (membrane sheets) and 3-dimensional (scanning) distributions of proteins across membranes that have dramatic changes in surface topography due to microvilli, ruffles, etc. Please see Wilson et al, JCB 154:645 and JCB 149:1131.
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