Editors' ChoiceMEDICINE

Faulty Scaffolding and Cancer

Science Signaling  25 Mar 2008:
Vol. 1, Issue 12, pp. ec113
DOI: 10.1126/stke.112ec113

Differentiation, survival, and growth of B cells requires proper functioning of the nuclear factor κB (NF-κB) signaling pathway, including CARD11, a cytoplasmic scaffolding protein that serves as a docking site for signaling molecules. Lenz et al. have discovered that a certain subtype of diffuse large B cell lymphoma (DLBCL), the most common form of non-Hodgkin’s lymphoma in humans, is caused by mutations in the CARD11 gene. In cell culture experiments, these mutant forms of CARD11 caused inappropriate activation of the NF-κB pathway.

G. Lenz, R. E. Davis, V. N. Ngo, L. Lam, T. C. George, G. W. Wright, S. S. Dave, H. Zhao, W. Xu, A. Rosenwald, G. Ott, H. K. Muller-Hermelink, R. D. Gascoyne, J. M. Connors, L. M. Rimsza, E. Campo, E. S. Jaffe, J. Delabie, E. B. Smeland, R. I. Fisher, W. C. Chan, L. M. Staudt, Oncogenic CARD11 mutations in human diffuse large B cell lymphoma. Science 319, 1676-1679 (2008). [Abstract] [Full Text]