Editorial GuideGENETICS

Focus Issue: Mechanisms of Gene Regulation

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Sci. Signal.  01 Apr 2008:
Vol. 1, Issue 13, pp. eg3
DOI: 10.1126/stke.113eg3

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In this Focus Issue of Science Signaling, which complements the Science Special Issue on Gene Regulation (http://www.sciencemag.org/generegulation/), we examine the multilayered mechanisms that control how gene expression is turned on or off. Perspectives in this issue discuss how oncogenic Ras directs the silencing of tumor suppressor genes; how intrachromosomal looping brings enhancers and promoters together to stimulate gene expression; and how the abundance of a transcriptional coactivator affects nuclear receptor–mediated transcription.

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