15 April 2008
Vol 1, Issue 15
  • Contents

    • Review

    • Journal Club

    • Editors' Choice

      • Bacterial TIR Domains

        Bacteria interfere with Toll-like receptor signaling by secreting proteins with TIR domains that compete with the MyD88 adaptor.

      • Follow the Endothelin

        Endothelin derived from blood vessels helps direct sympathetic neurons to their target organs.

      • Keeping Axons on Track

        In mice, axons carrying signals from spinal cord to muscle are kept separate from those going in the opposite direction by ephrin signaling between them.

      • Slow Breathing

        AKAP121 degradation leads to decreased mitochondrial metabolism under hypoxic conditions.

      • Balancing Stability and Dynamics

        Precise control of adhesive properties is essential for collective migration.

      • Bcl2 Blocks DNA Repair

        In the nucleus, Bcl2 interacts with apurinic/apyrimidinic endonuclease 1 (APE1) to inhibit DNA repair.

      • Radioprotection: Taking the Toll Road

        A drug that triggers the pathway that cancer cells use to avoid death can protect healthy cells from the harmful effects of radiation treatment.

      • Fast Receptors in Every Respect

        Desensitized glutamate receptors are exchanged for functional ones through lateral movement within membranes to help maintain fast excitatory neurotransmission.

About The Cover

Cover image expansion

COVER This week's issue includes a Review that discusses the importance of the interactions between Eph receptors and their membrane-bound ephrin ligands in normal and oncogenic development. The image shows EphB2 (green) in a complex with ephrin A5 (blue) and is adapted from PDB structure 1shw. [Image: Christopher Bickel, AAAS]